The DREAM Study
A randomised controlled trial assessing Desensitisation to cow's milk, following partially or extensively hydrolysed formulae feeding REgimens, in children with Allergy to cow's Milk (The DREAM study).
Cow's milk allergy (CMA) is a response by the body in which proteins in cow's milk are recognised as a foreign substance and the immune system reacts to them by developing allergic symptoms.
CMA is one of the most common food allergies in infants, however, there is no standardised way to treat it. Current guidelines suggest complete avoidance of all products containing cow's milk and waiting for the allergy to resolve spontaneously. The 'Milk Ladder' is also supported, which involves slowly reintroducing processed milk and dairy products back into the baby's diet however, the Milk Ladder is not always suitable for all babies with cow's milk allergy.
The aim of the trial is to find out whether one year of feeding with a partially hydrolysed formula milk is more effective than feeding with an extensively hydrolysed formula milk, as a treatment for 6-12 month old infants with moderate-severe cow's milk allergy.